Ketoconazole Coadministration of bosentan one hundred twenty five mg twice day by day and ketoconazole, a powerful CYP3A inhibitor, greater the plasma concentrations of bosentan by around one hundred% in normal volunteers. No dose adjustment of bosentan is necessary, but greater effects of bosentan need to be considered. We can https://tracleer52730.thelateblog.com/26553242/the-basic-principles-of-bosentan