Prescribers should observe serum valproate concentrations and medical reaction when incorporating or discontinuing methotrexate and alter valproate dosage, if important. Patients stabilized on rufinamide right before getting prescribed valproate need to start out valproate therapy in a low dose, and titrate to a clinically successful dose [see DRUG INTERACTIONS]. DailyMed https://michaelr382jqv3.livebloggs.com/profile