You will find a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent suffering transmission and generate analgesia. Thus, medicines like clonidine that goal alpha-2 receptors can affect the transmission of pain. : connected to, served by, or https://www.proleviate.com/post/the-new-pain-killer-conolidine